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Lysosomal chloride transporter CLH-6 protects lysosome membrane integrity via cathepsin activation

Lysosomal integrity is vital for cell homeostasis, but the underlying mechanisms are poorly understood. Here, we identify CLH-6, the C. elegans ortholog of the lysosomal Cl(−)/H(+) antiporter ClC-7, as an important factor for protecting lysosomal integrity. Loss of CLH-6 affects lysosomal degradatio...

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Detalles Bibliográficos
Autores principales:	Zhang, Qianqian, Li, Yuan, Jian, Youli, Li, Meijiao, Wang, Xiaochen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114921/ https://www.ncbi.nlm.nih.gov/pubmed/37058288 http://dx.doi.org/10.1083/jcb.202210063

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