Probing mutation-induced conformational transformation of the GTP/M-RAS complex through Gaussian accelerated molecular dynamics simulations

Mutations highly affect the structural flexibility of two switch domains in M-RAS considered an important target of anticancer drug design. Gaussian accelerated molecular dynamics (GaMD) simulations were applied to probe the effect of mutations P40D, D41E, and P40D/D41E/L51R on the conformational tr...

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Detalles Bibliográficos
Autores principales: Bao, Huayin, Wang, Wei, Sun, Haibo, Chen, Jianzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114971/
https://www.ncbi.nlm.nih.gov/pubmed/37057639
http://dx.doi.org/10.1080/14756366.2023.2195995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114971/
https://www.ncbi.nlm.nih.gov/pubmed/37057639
http://dx.doi.org/10.1080/14756366.2023.2195995

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