Triple targeting of mutant EGFR(L858R/T790M), COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti-inflammatory and anticancer evaluation

We designed and synthesised novel quinazolinone tethered phenyl urea derivatives (6a–p) that triple target the double mutant EGFR(L858R/T790M), COX-2, and 15-LOX. Compounds (6e, 6d, 6j, 6m, and 6n) not only had low micromolar IC50 inhibitory activities against the three targets, but they also showed...

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Detalles Bibliográficos
Autores principales: Kothayer, Hend, Rezq, Samar, Abdelkhalek, Ahmed S., Romero, Damian G., Elbaramawi, Samar S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114980/
https://www.ncbi.nlm.nih.gov/pubmed/37038884
http://dx.doi.org/10.1080/14756366.2023.2199166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114980/
https://www.ncbi.nlm.nih.gov/pubmed/37038884
http://dx.doi.org/10.1080/14756366.2023.2199166

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