A novel dopamine receptor D2 antagonist (ONC206) potentiates the effects of olaparib in endometrial cancer

Poly ADP-ribose polymerase (PARP) inhibitors are effective therapies for cancer patients with homologous recombination (HR) deficient tumors. The imipridone ONC206 is an orally bioavailable dopamine receptor D2 antagonist and mitochondrial protease ClpP agonist that has anti-tumorigenic effects in e...

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Detalles Bibliográficos
Autores principales: Paraghamian, Sarah E., Qiu, Jianqing, Hawkins, Gabrielle M., Zhao, Ziyi, Sun, Wenchuan, Fan, Yali, Zhang, Xin, Suo, Hongyan, Hao, Tianran, Prabhu, Varun Vijay, Allen, Joshua E., Zhou, Chunxiao, Bae-Jump, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115124/
https://www.ncbi.nlm.nih.gov/pubmed/37069726
http://dx.doi.org/10.1080/15384047.2023.2202104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115124/
https://www.ncbi.nlm.nih.gov/pubmed/37069726
http://dx.doi.org/10.1080/15384047.2023.2202104

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