Cargando…

A novel dopamine receptor D2 antagonist (ONC206) potentiates the effects of olaparib in endometrial cancer

Poly ADP-ribose polymerase (PARP) inhibitors are effective therapies for cancer patients with homologous recombination (HR) deficient tumors. The imipridone ONC206 is an orally bioavailable dopamine receptor D2 antagonist and mitochondrial protease ClpP agonist that has anti-tumorigenic effects in e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paraghamian, Sarah E., Qiu, Jianqing, Hawkins, Gabrielle M., Zhao, Ziyi, Sun, Wenchuan, Fan, Yali, Zhang, Xin, Suo, Hongyan, Hao, Tianran, Prabhu, Varun Vijay, Allen, Joshua E., Zhou, Chunxiao, Bae-Jump, Victoria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115124/ https://www.ncbi.nlm.nih.gov/pubmed/37069726 http://dx.doi.org/10.1080/15384047.2023.2202104

Ejemplares similares

ONC206, an Imipridone Derivative, Induces Cell Death Through Activation of the Integrated Stress Response in Serous Endometrial Cancer In Vitro
por: Zhang, Yingao, et al.
Publicado: (2020)

Asparagus officinalis combined with paclitaxel exhibited synergistic anti-tumor activity in paclitaxel-sensitive and -resistant ovarian cancer cells
por: Zhang, Xin, et al.
Publicado: (2022)

Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer
por: Pierce, Stuart R., et al.
Publicado: (2021)

Ipatasertib exhibits anti-tumorigenic effects and enhances sensitivity to paclitaxel in endometrial cancer in vitro and in vivo
por: O'donnell, Jillian, et al.
Publicado: (2023)

Oleic Acid Exhibits Anti-Proliferative and Anti-Invasive Activities via the PTEN/AKT/mTOR Pathway in Endometrial Cancer
por: Deng, Boer, et al.
Publicado: (2023)

MODL-06. PRECLINICAL EFFICACY OF THE IMIPRIDONE ONC-206 AGAINST MEDULLOBLASTOMA
por: Malhotra, Anshu, et al.
Publicado: (2020)

Anti-Tumor and Anti-Invasive Effects of ONC201 on Ovarian Cancer Cells and a Transgenic Mouse Model of Serous Ovarian Cancer
por: Fan, Yali, et al.
Publicado: (2022)

Inhibition of CDK1 by RO-3306 Exhibits Anti-Tumorigenic Effects in Ovarian Cancer Cells and a Transgenic Mouse Model of Ovarian Cancer
por: Huang, Yu, et al.
Publicado: (2023)

A Novel Therapeutic Mechanism of Imipridones ONC201/ONC206 in MYCN-Amplified Neuroblastoma Cells via Differential Expression of Tumorigenic Proteins
por: El-Soussi, Sarra, et al.
Publicado: (2021)

Asparagus officinalis Exhibits Anti-Tumorigenic and Anti-Metastatic Effects in Ovarian Cancer
por: Xu, Guangxu, et al.
Publicado: (2021)

Orlistat exerts anti-obesity and anti-tumorigenic effects in a transgenic mouse model of endometrial cancer
por: Xu, Guangxu, et al.
Publicado: (2023)

Role of Dopamine Receptors in the Anticancer Activity of ONC201()()
por: Kline, Christina Leah B., et al.
Publicado: (2017)

Ipatasertib, an oral AKT inhibitor, in combination with carboplatin exhibits anti-proliferative effects in uterine serous carcinoma
por: Burkett, Wesley C., et al.
Publicado: (2023)

CLRM-02 SINGLE CENTER EXPERIENCE OF DOPAMINE ANTAGONIST ONC-201 FOR RECURRENT H3K27M-MUTANT GLIOBLASTOMA IN ADULTS
por: Ekhator, Chukwuyem, et al.
Publicado: (2022)

At R206
por: CERN PhotoLab
Publicado: (1976)

Mutations of Human DopamineTransporter at Tyrosine88, Aspartic Acid206, and Histidine547 Influence Basal and HIV-1 Tat‐inhibited Dopamine Transport
por: Quizon, Pamela M., et al.
Publicado: (2021)

Tissue factor–positive extracellular vesicles in plasma are not associated with venous thromboembolism in patients with ovarian cancer
por: Hisada, Yohei, et al.
Publicado: (2023)

CPLEAR, I206
por: Peach, Kenneth J
Publicado: (1995)

Olaparib in the management of ovarian cancer
por: Bixel, Kristin, et al.
Publicado: (2015)

Olaparib in Epithelial Ovarian Cancer
por: Anastasia, Paula J.
Publicado: (2016)

Olaparib: Transcending mutational barriers
por: Chandna, Abhishek
Publicado: (2019)

Olaparib and somatic BRCA mutations
por: George, Angela, et al.
Publicado: (2017)

Curul 206 : una visión del Congreso
por: Clouthier Carrillo, Tatiana
Publicado: (2006)

Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration
por: Stein, Mark N., et al.
Publicado: (2019)

Roles of dopamine receptors and their antagonist thioridazine in hepatoma metastasis
por: Lu, Meiling, et al.
Publicado: (2015)

Dopamine receptor antagonists as potential therapeutic agents for ADPKD
por: Paul, Parama, et al.
Publicado: (2019)

M198. INVESTIGATIONAL DOPAMINE ANTAGONISTS FOR THE TREATMENT OF SCHIZOPHRENIA
Publicado: (2020)

The Effects of NT-1044, a Novel AMPK Activator, on Endometrial Cancer Cell Proliferation, Apoptosis, Cell Stress and In Vivo Tumor Growth
por: Roque, Dario R., et al.
Publicado: (2021)

A Single-Center Experience of Dopamine Antagonist ONC201 for Recurrent Histone H3 Lysine 27-to-Methionine (H3K27M)-Mutant Glioblastoma in Adults
por: Ekhator, Chukwuyem, et al.
Publicado: (2022)

The combination of olaparib and camptothecin for effective radiosensitization
por: Miura, Katsutoshi, et al.
Publicado: (2012)

206. Variations in the frequency and impact of polymicrobial cultures in adults with invasive Group B Streptococcal (GBS) infection at the US Veterans Health Administration
por: Briggs, Janet, et al.
Publicado: (2019)

The decay properties of $^{206}Hg$ and the $^{208}Pb(p,3p) ^{206}Hg$ reaction
por: Wolf, G K
Publicado: (1968)

Olaparib Monotherapy for BRIP1-Mutated High-Grade Serous Endometrial Cancer
por: Nakamura, Kohei, et al.
Publicado: (2020)

The effect of a dopamine antagonist on conditioning of sexual arousal in women
por: Brom, Mirte, et al.
Publicado: (2016)

Single exposure of dopamine D1 antagonist prevents and D2 antagonist attenuates methylphenidate effect
por: Claussen, Catherine M, et al.
Publicado: (2015)

Profile of olaparib in the treatment of advanced ovarian cancer
por: Chase, Dana M, et al.
Publicado: (2016)

Olaparib-Induced Immune-Mediated Liver Injury
por: Alshelleh, Mohammad, et al.
Publicado: (2022)

A case of hand-foot syndrome with olaparib
por: da Costa, Rafael Everton Assunção Ribeiro, et al.
Publicado: (2022)

The ($d$,$p$) reaction on $^{206}$Hg
por: Kay, B, et al.
Publicado: (2016)

206 Implementing an Antimicrobial Stewardship Program
por: Vassallo, Angela, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_pkuusl0i8q64e1gm4ksgca96hg