Epac1 and PKA agonists inhibit ROS to reduce NLRP3 inflammasome proteins in retinal endothelial cells

PURPOSE: Reactive oxygen species (ROS) activate inflammatory pathways in several organs, including the retina. More recent work has shown that ROS activate the NOD-like receptor protein 3 (NLRP3) inflammasome pathway proteins. We recently showed that the exchange protein activated by cAMP 1 (Epac1)...

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Detalles Bibliográficos
Autores principales: Liu, Li, Jiang, Youde, Steinle, Jena J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115359/
https://www.ncbi.nlm.nih.gov/pubmed/37089701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115359/
https://www.ncbi.nlm.nih.gov/pubmed/37089701

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