BBB opening with focused ultrasound in nonhuman primates and Parkinson’s disease patients: Targeted AAV vector delivery and PET imaging

Intracerebral vector delivery in nonhuman primates has been a major challenge. We report successful blood-brain barrier opening and focal delivery of adeno-associated virus serotype 9 vectors into brain regions involved in Parkinson’s disease using low-intensity focus ultrasound in adult macaque mon...

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Detalles Bibliográficos
Autores principales: Blesa, Javier, Pineda-Pardo, José A., Inoue, Ken-ichi, Gasca-Salas, Carmen, Balzano, Tiziano, Del Rey, Natalia López-González, Reinares-Sebastián, Alejandro, Esteban-García, Noelia, Rodríguez-Rojas, Rafael, Márquez, Raquel, Ciorraga, María, del Álamo, Marta, García-Cañamaque, Lina, Ruiz de Aguiar, Santiago, Rachmilevitch, Itay, Trigo-Damas, Inés, Takada, Masahiko, Obeso, José A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115413/
https://www.ncbi.nlm.nih.gov/pubmed/37075119
http://dx.doi.org/10.1126/sciadv.adf4888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115413/
https://www.ncbi.nlm.nih.gov/pubmed/37075119
http://dx.doi.org/10.1126/sciadv.adf4888

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