RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription

Mixed-lineage leukemia 1 (MLL1) is a transcription activator of the HOX family, which binds to specific epigenetic marks on histone H3 through its third plant homeodomain (PHD3) domain. Through an unknown mechanism, MLL1 activity is repressed by cyclophilin 33 (Cyp33), which binds to MLL1 PHD3. We d...

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Detalles Bibliográficos
Autores principales: Blatter, Markus, Meylan, Charlotte, Cléry, Antoine, Giambruno, Roberto, Nikolaev, Yaroslav, Heidecker, Michel, Solanki, Jessica Arvindbhai, Diaz, Manuel O., Gabellini, Davide, Allain, Frédéric H.-T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115415/
https://www.ncbi.nlm.nih.gov/pubmed/37075125
http://dx.doi.org/10.1126/sciadv.adf5330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115415/
https://www.ncbi.nlm.nih.gov/pubmed/37075125
http://dx.doi.org/10.1126/sciadv.adf5330

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