Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencing

Immunoglobulin loci-transgenic animals are widely used in antibody discovery and increasingly in vaccine response modelling. In this study, we phenotypically characterised B-cell populations from the Intelliselect Transgenic mouse (Kymouse) demonstrating full B-cell development competence. Compariso...

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Detalles Bibliográficos
Autores principales: Richardson, Eve, Binter, Špela, Kosmac, Miha, Ghraichy, Marie, von Niederhäusern, Valentin, Kovaltsuk, Aleksandr, Galson, Jacob D, Trück, Johannes, Kelly, Dominic F, Deane, Charlotte M, Kellam, Paul, Watson, Simon J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115447/
https://www.ncbi.nlm.nih.gov/pubmed/36971345
http://dx.doi.org/10.7554/eLife.81629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115447/
https://www.ncbi.nlm.nih.gov/pubmed/36971345
http://dx.doi.org/10.7554/eLife.81629

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