Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines

Transactivating response region DNA binding protein 43 (TDP-43) pathology is prevalent in dementia, but the cell type–specific effects of TDP-43 pathology are not clear, and therapeutic strategies to alleviate TDP-43–linked cognitive decline are lacking. We found that patients with Alzheimer’s disea...

Descripción completa

Detalles Bibliográficos
Autores principales: Licht-Murava, Avital, Meadows, Samantha M., Palaguachi, Fernando, Song, Soomin C., Jackvony, Stephanie, Bram, Yaron, Zhou, Constance, Schwartz, Robert E., Froemke, Robert C., Orr, Adam L., Orr, Anna G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115456/
https://www.ncbi.nlm.nih.gov/pubmed/37075107
http://dx.doi.org/10.1126/sciadv.ade1282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115456/
https://www.ncbi.nlm.nih.gov/pubmed/37075107
http://dx.doi.org/10.1126/sciadv.ade1282

Ejemplares similares