De novo design of modular peptide-binding proteins by superhelical matching

General approaches for designing sequence-specific peptide-binding proteins would have wide utility in proteomics and synthetic biology. However, designing peptide-binding proteins is challenging, as most peptides do not have defined structures in isolation, and hydrogen bonds must be made to the bu...

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Autores principales: Wu, Kejia, Bai, Hua, Chang, Ya-Ting, Redler, Rachel, McNally, Kerrie E., Sheffler, William, Brunette, T. J., Hicks, Derrick R., Morgan, Tomos E., Stevens, Tim J., Broerman, Adam, Goreshnik, Inna, DeWitt, Michelle, Chow, Cameron M., Shen, Yihang, Stewart, Lance, Derivery, Emmanuel, Silva, Daniel Adriano, Bhabha, Gira, Ekiert, Damian C., Baker, David
格式: Online Artículo Texto
語言:English
出版: Nature Publishing Group UK 2023
主題:
Article
在線閱讀:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115654/
https://www.ncbi.nlm.nih.gov/pubmed/37020023
http://dx.doi.org/10.1038/s41586-023-05909-9

因特網

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115654/
https://www.ncbi.nlm.nih.gov/pubmed/37020023
http://dx.doi.org/10.1038/s41586-023-05909-9

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