PAM-flexible Cas9-mediated base editing of a hemophilia B mutation in induced pluripotent stem cells

BACKGROUND: Base editing via CRISPR-Cas9 has garnered attention as a method for correcting disease-specific mutations without causing double-strand breaks, thereby avoiding large deletions and translocations in the host chromosome. However, its reliance on the protospacer adjacent motif (PAM) can li...

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Detalles Bibliográficos
Autores principales: Hiramoto, Takafumi, Kashiwakura, Yuji, Hayakawa, Morisada, Baatartsogt, Nemekhbayar, Kamoshita, Nobuhiko, Abe, Tomoyuki, Inaba, Hiroshi, Nishimasu, Hiroshi, Uosaki, Hideki, Hanazono, Yutaka, Nureki, Osamu, Ohmori, Tsukasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115777/
https://www.ncbi.nlm.nih.gov/pubmed/37076593
http://dx.doi.org/10.1038/s43856-023-00286-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115777/
https://www.ncbi.nlm.nih.gov/pubmed/37076593
http://dx.doi.org/10.1038/s43856-023-00286-w

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