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Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1

Neuronal apoptosis has been well-recognized as a critical mediator in the pathogenesis of depressive disorders. Tissue kallikrein-related peptidase 8 (KLK8), a trypsin-like serine protease, has been implicated in the pathogenesis of several psychiatric disorders. The present study aimed to explore t...

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Detalles Bibliográficos
Autores principales: Xu, Dan-Hong, Du, Jian-Kui, Liu, Shi-Yu, Zhang, Hui, Yang, Lu, Zhu, Xiao-Yan, Liu, Yu-Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115824/
https://www.ncbi.nlm.nih.gov/pubmed/37076499
http://dx.doi.org/10.1038/s41419-023-05800-5