Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson’s disease

Accumulation of α-synuclein into toxic oligomers or fibrils is implicated in dopaminergic neurodegeneration in Parkinson’s disease. Here we performed a high-throughput, proteome-wide peptide screen to identify protein-protein interaction inhibitors that reduce α-synuclein oligomer levels and their a...

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Detalles Bibliográficos
Autores principales: Nim, Satra, O’Hara, Darren M., Corbi-Verge, Carles, Perez-Riba, Albert, Fujisawa, Kazuko, Kapadia, Minesh, Chau, Hien, Albanese, Federica, Pawar, Grishma, De Snoo, Mitchell L., Ngana, Sophie G., Kim, Jisun, El-Agnaf, Omar M. A., Rennella, Enrico, Kay, Lewis E., Kalia, Suneil K., Kalia, Lorraine V., Kim, Philip M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115881/
https://www.ncbi.nlm.nih.gov/pubmed/37076542
http://dx.doi.org/10.1038/s41467-023-37464-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115881/
https://www.ncbi.nlm.nih.gov/pubmed/37076542
http://dx.doi.org/10.1038/s41467-023-37464-2

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