Turning up the heat mimics allosteric signaling in imidazole-glycerol phosphate synthase

Allosteric drugs have the potential to revolutionize biomedicine due to their enhanced selectivity and protection against overdosage. However, we need to better understand allosteric mechanisms in order to fully harness their potential in drug discovery. In this study, molecular dynamics simulations...

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Detalles Bibliográficos
Autores principales: Maschietto, Federica, Morzan, Uriel N., Tofoleanu, Florentina, Gheeraert, Aria, Chaudhuri, Apala, Kyro, Gregory W., Nekrasov, Peter, Brooks, Bernard, Loria, J. Patrick, Rivalta, Ivan, Batista, Victor S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115891/
https://www.ncbi.nlm.nih.gov/pubmed/37076500
http://dx.doi.org/10.1038/s41467-023-37956-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115891/
https://www.ncbi.nlm.nih.gov/pubmed/37076500
http://dx.doi.org/10.1038/s41467-023-37956-1

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