Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase

Monkeypox is a disease with pandemic potential. It is caused by the monkeypox virus (MPXV), a double-stranded DNA virus from the Poxviridae family, that replicates in the cytoplasm and must encode for its own RNA processing machinery including the capping machinery. Here, we present crystal structur...

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Detalles Bibliográficos
Autores principales: Silhan, Jan, Klima, Martin, Otava, Tomas, Skvara, Petr, Chalupska, Dominika, Chalupsky, Karel, Kozic, Jan, Nencka, Radim, Boura, Evzen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116469/
https://www.ncbi.nlm.nih.gov/pubmed/37080993
http://dx.doi.org/10.1038/s41467-023-38019-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116469/
https://www.ncbi.nlm.nih.gov/pubmed/37080993
http://dx.doi.org/10.1038/s41467-023-38019-1

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