Cargando…

Microwave-Assisted Synthesis, Structure, and Preliminary Biological Evaluation of Novel 6-Methoxy-5,6-dihydro-5-azapurines

[Image: see text] We herein disclose the microwave-assisted synthesis of previously unreported 6-methoxy-5,6-dihydro-5-azapurines, whose purine-like scaffold is promising for drug discovery. The method is simple, fast, and relies on easily accessible reagents such as trimethyl orthoformate, acetic a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siutkina, Alena I., Kalinina, Svetlana, Liu, Rongfang, Heitman, Laura H., Junker, Anna, Daniliuc, Constantin G., Kalinin, Dmitrii V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116508/ https://www.ncbi.nlm.nih.gov/pubmed/37091407 http://dx.doi.org/10.1021/acsomega.3c00765

Ejemplares similares

6α-Hydroxy-5,6-dihydrosalviasperanol
por: Asik, Safra Izuani Jama, et al.
Publicado: (2010)

Synthesis, solvatochromism and crystal structure of 5-Methoxy-5,6-diphenyl-4,5-dihydro-2H −1,2,4-triazine-3-thione
por: Rezaei, Behrooz, et al.
Publicado: (2013)

5,6-Di-2-thienyl-2,3-dihydropyrazine
por: Hemamalini, Madhukar, et al.
Publicado: (2010)

Pyrazole-Based Thrombin Inhibitors with a Serine-Trapping Mechanism of Action: Synthesis and Biological Activity
por: Dunker, Calvin, et al.
Publicado: (2022)

2-Chloro-6,6-dimethyl-5,6-dihydroindazolo[2,3-c]quinazoline
por: Boechat, Núbia, et al.
Publicado: (2010)

2-(5,6-Dihydrobenzimidazo[1,2-c]quinazolin-6-yl)-5-methylphenol
por: Eltayeb, Naser Eltaher, et al.
Publicado: (2011)

2-(5,6-Dihydrobenzimidazo[1,2-c]quinazolin-6-yl)phenol
por: Eltayeb, Naser Eltaher, et al.
Publicado: (2011)

(6S*)-6-[(1S*,2R*)-1,2-Dihydroxypentyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
por: Valenti, Domenic J., et al.
Publicado: (2013)

8-Chloro-5,5-dimethyl-5,6-dihydrotetrazolo[1,5-c]quinazoline
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

2-(5,6-Dihydrobenzimidazo[1,2-c]quinazolin-6-yl)-5-methoxyphenol
por: Eltayeb, Naser Eltaher, et al.
Publicado: (2011)

Microwave-assisted efficient one-pot synthesis of N(2)-(tetrazol-5-yl)-6-aryl/heteroaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines
por: Moustafa, Moustafa Sherief, et al.
Publicado: (2020)

6-(2-Fluorophenyl)-5,6-dihydrobenzimidazolo[1,2-c]quinazoline
por: Li, Ai-Ke, et al.
Publicado: (2008)

Synthesis of Natural Homoisoflavonoids Having Either 5,7-Dihydroxy-6-methoxy or 7-Hydroxy-5,6-dimethoxy Groups
por: Lee, Hyungjun, et al.
Publicado: (2016)

2-(5,6-Dihydrobenzimidazo[1,2-c]quinazolin-6-yl)-6-ethoxyphenol
por: Eltayeb, Naser Eltaher, et al.
Publicado: (2011)

In vitro antitumour activity of cis- and trans-5-fluoro-5,6-dihydro-6-alkoxy-uracils; effects on thymidylate synthesis.
por: van der Wilt, C. L., et al.
Publicado: (1993)

5,6-Dichloro-2-(3-methoxyphenyl)isoindoline-1,3-dione
por: Büyükgüngör, Orhan, et al.
Publicado: (2008)

Dihydro-5,6-dehydrokavain (DDK) from Alpinia zerumbet: Its Isolation, Synthesis, and Characterization
por: Xuan, Tran Dang, et al.
Publicado: (2015)

5-(4-Chlorophenyl)-6-isopropyl-5,6-dihydro-4H-pyrrolo[3,4-c]isoxazole
por: Ha, Kwang, et al.
Publicado: (2010)

7-(Benzylsulfanyl)-5-(2-methoxyphenyl)-1,3-dimethyl-5,6-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
por: Bazgir, Ayoob, et al.
Publicado: (2008)

7-Pivaloyl-5,6-dihydro-4H-naphtho[3,2,1-de]isoquinoline-4,6-dione
por: Yu, Hai-Tao, et al.
Publicado: (2010)

(4S,5S,6S)-4-Hydroxy-3-methoxy-5-methyl-5,6-epoxycyclohex-2-en-1-one
por: Tansuwan, Srinuan, et al.
Publicado: (2010)

Ethyl 5-hydroxy-6-oxo-4-phenyl-5,6-dihydro-4H-cyclopenta[b]thiophene-5-carboxylate
por: McAdam, C. John, et al.
Publicado: (2011)

5,6-Dihydro-2H-1,3-dithiolo[4,5-b][1,4]dioxine-2-thione
por: Wang, Guan-nan, et al.
Publicado: (2011)

5-(4-Methylphenyl)-2,3-diphenyl-5,6-dihydroimidazo[1,2-c]quinazoline
por: Zhang, Jiankang, et al.
Publicado: (2010)

2-(2-Chlorophenyl)-3-methyl-5,6-diphenyl-2,3-dihydropyrazine
por: Anuradha, N., et al.
Publicado: (2011)

Ethyl 2-phenyl-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate
por: Yu, Zhao-Peng, et al.
Publicado: (2012)

2-Methyl-3-(4-methylphenyl)-5,6-diphenyl-2,3-dihydropyrazine
por: Thiruvalluvar, A., et al.
Publicado: (2012)

5,6-Dihydro-1,4-dithiine-2,3-dicarboxylic anhydride
por: Bullock, Olivia, et al.
Publicado: (2023)

(S)-6-{[(S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methyl}-5,5-difluoro-5,6-dihydro-2H-pyran-2-one
por: Yin, Zengsheng, et al.
Publicado: (2009)

O5.6. Submission Withdrawn
Publicado: (2018)

2-(3-Chloro-5,6-diphenyl-2,5-dihydro-1,2,4-triazin-5-yl)-2-methylpropanenitrile
por: Wolińska, Ewa, et al.
Publicado: (2012)

5-Hydroxy-6-[(E)-2-phenylethenyl]-5,6-dihydro-2H-pyran-2-one isolated from Goniothalamus ridleyi
por: Jusoh, Samsiah, et al.
Publicado: (2012)

4-(5,6-Dihydrobenzimidazo[1,2-c]quinazolin-6-yl)benzene-1,3-diol dimethyl sulfoxide monosolvate
por: Eltayeb, Naser Eltaher, et al.
Publicado: (2011)

N-(2,6-Dimethylanilino)-5,6-dihydro-4H-1,3-thiazin-3-ium chloride monohydrate
por: Veidis, Mikelis V., et al.
Publicado: (2008)

6-(2-Hydroxyphenyl)-5,6-dihydrobenzimidazolo[1,2-c]quinazolin-12-ium bromide ethanol solvate
por: Booysen, Irvin, et al.
Publicado: (2009)

5,6-Dihydro-1,10-phenanthroline-1,10-diium μ-oxido-bis[pentafluoridotantalate(V)]
por: Meng, Zhao-Hui, et al.
Publicado: (2012)

2-Amino-4-(2-fluorophenyl)-5,6-dihydrobenzo[h]quinoline-3-carbonitrile
por: Wang, Wei, et al.
Publicado: (2010)

Ethyl 5-oxo-4-phenyl-5,6-dihydro-4H-1,3,4-oxadiazine-2-carboxylate
por: Shubakara, K., et al.
Publicado: (2014)

4,6-Dichloro-5-methoxypyrimidine
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

Comparative Study of the Effect of 5,6-Dihydroergosterol and 3-epi-5,6-dihydroergosterol on Chemokine Expression in Human Keratinocytes
por: Park, Ye Seul, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_80hp8n7c7v6ojcrplvbpgrsj8t