Prediction for Plasma Trough Concentration and Optimal Dosing of Imatinib under Multiple Clinical Situations Using Physiologically Based Pharmacokinetic Modeling

[Image: see text] (1) Purpose: This study aimed to develop a physiologically based pharmacokinetic (PBPK) model to predict the trough concentration (C(trough)) of imatinib (IMA) at steady state in patients and to explore the role of free concentration (f(up)), α1-acid glycoprotein (AGP) level, and o...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Dongmei, Wang, Guopeng, Wu, Honghai, Wu, JinHua, Zhao, Xiaoang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116519/
https://www.ncbi.nlm.nih.gov/pubmed/37091368
http://dx.doi.org/10.1021/acsomega.2c07967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116519/
https://www.ncbi.nlm.nih.gov/pubmed/37091368
http://dx.doi.org/10.1021/acsomega.2c07967

Ejemplares similares