Allosteric Regulation of Glycogen Phosphorylase by Order/Disorder Transition of the 250′ and 280s Loops

[Image: see text] Allostery is a fundamental mechanism of protein activation, yet the precise dynamic changes that underlie functional regulation of allosteric enzymes, such as glycogen phosphorylase (GlyP), remain poorly understood. Despite being the first allosteric enzyme described, its structura...

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Detalles Bibliográficos
Autores principales: Kish, Monika, Subramanian, Sivaraman, Smith, Victoria, Lethbridge, Natasha, Cole, Lindsay, Vollmer, Frank, Bond, Nicholas. J., Phillips, Jonathan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116597/
https://www.ncbi.nlm.nih.gov/pubmed/36989206
http://dx.doi.org/10.1021/acs.biochem.2c00671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116597/
https://www.ncbi.nlm.nih.gov/pubmed/36989206
http://dx.doi.org/10.1021/acs.biochem.2c00671

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