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Allosteric Regulation of Glycogen Phosphorylase by Order/Disorder Transition of the 250′ and 280s Loops
[Image: see text] Allostery is a fundamental mechanism of protein activation, yet the precise dynamic changes that underlie functional regulation of allosteric enzymes, such as glycogen phosphorylase (GlyP), remain poorly understood. Despite being the first allosteric enzyme described, its structura...
Autores principales: | Kish, Monika, Subramanian, Sivaraman, Smith, Victoria, Lethbridge, Natasha, Cole, Lindsay, Vollmer, Frank, Bond, Nicholas. J., Phillips, Jonathan J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116597/ https://www.ncbi.nlm.nih.gov/pubmed/36989206 http://dx.doi.org/10.1021/acs.biochem.2c00671 |
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