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Role of the Mycobacterium tuberculosis ESX-4 Secretion System in Heme Iron Utilization and Pore Formation by PPE Proteins

Mycobacterium tuberculosis (Mtb) is transmitted through aerosols and primarily colonizes within the lung. The World Health Organization estimates that Mtb kills ~1.4 million people every year. A key aspect that makes Mtb such a successful pathogen is its ability to overcome iron limitation mounted b...

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Detalles Bibliográficos
Autores principales: Sankey, November, Merrick, Haley, Singh, Padam, Rogers, Janet, Reddi, Amit, Hartson, Steven D., Mitra, Avishek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117145/
https://www.ncbi.nlm.nih.gov/pubmed/36749044
http://dx.doi.org/10.1128/msphere.00573-22