Differences in tissue distribution ability of evodiamine and dehydroevodiamine are due to the dihedral angle of the molecule stereo-structure

Introduction: This researcher focused at the evodiamine and dehydroevodiamine tissue distribution and structure-pharmacokinetics (PK) relationship after intravenous injection in mice. Methods: Using a transmembrane transport experiment, the permeability of evodiamine and dehydroevodiamine on Caco-2...

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Detalles Bibliográficos
Autores principales: Luo, Jie, Wen, Wen, Chen, Jie, Zeng, Xiaobo, Wang, Ping, Xu, Shijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117637/
https://www.ncbi.nlm.nih.gov/pubmed/37089948
http://dx.doi.org/10.3389/fphar.2023.1109279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117637/
https://www.ncbi.nlm.nih.gov/pubmed/37089948
http://dx.doi.org/10.3389/fphar.2023.1109279

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