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Differences in tissue distribution ability of evodiamine and dehydroevodiamine are due to the dihedral angle of the molecule stereo-structure
Introduction: This researcher focused at the evodiamine and dehydroevodiamine tissue distribution and structure-pharmacokinetics (PK) relationship after intravenous injection in mice. Methods: Using a transmembrane transport experiment, the permeability of evodiamine and dehydroevodiamine on Caco-2...
Autores principales: | Luo, Jie, Wen, Wen, Chen, Jie, Zeng, Xiaobo, Wang, Ping, Xu, Shijun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117637/ https://www.ncbi.nlm.nih.gov/pubmed/37089948 http://dx.doi.org/10.3389/fphar.2023.1109279 |
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