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βγ G-proteins, but not regulators of G-protein signaling 4, modulate opioid-induced respiratory rate depression
Opioid medications are the mainstay of pain management but present substantial side-effects such as respiratory depression which can be lethal with overdose. Most opioid drugs, such as fentanyl, act on opioid receptors such as the G-protein-coupled µ-opioid receptors (MOR). G-protein-coupled recepto...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117644/ https://www.ncbi.nlm.nih.gov/pubmed/37089428 http://dx.doi.org/10.3389/fphys.2023.1043581 |