Analysis of intracellular tyrosine phosphorylation in circulating neutrophils as a rapid assay for the in vivo effect of oral tyrosine kinase inhibitors

Tyrosine kinases are crucial signaling components of diverse biological processes and are major therapeutic targets in various malignancies and immune-mediated disorders. A critical step of development of novel tyrosine kinase inhibitors is the transition from the confirmation of the in vitro effect...

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Detalles Bibliográficos
Autores principales: Futosi, Krisztina, Bajza, Boglárka, Deli, Dorottya, Erdélyi, András, Tusnády, Simon, Mócsai, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117656/
https://www.ncbi.nlm.nih.gov/pubmed/37089957
http://dx.doi.org/10.3389/fphar.2023.1056154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117656/
https://www.ncbi.nlm.nih.gov/pubmed/37089957
http://dx.doi.org/10.3389/fphar.2023.1056154

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