The small molecule inhibitor BX-795 uncouples IL-2 production from inhibition of Th2 inflammation and induces CD4(+) T cells resembling iTreg

BACKGROUND: Treg cells have been shown to be an important part of immune-homeostasis and IL-2 which is produced upon T cell receptor (TCR)-dependent activation of T lymphocytes has been demonstrated to critically participate in Treg development. OBJECTIVE: To evaluate small molecule inhibitors (SMI)...

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Detalles Bibliográficos
Autores principales: Tauber, Peter A., Kratzer, Bernhard, Schatzlmaier, Philipp, Smole, Ursula, Köhler, Cordula, Rausch, Lisa, Kranich, Jan, Trapin, Doris, Neunkirchner, Alina, Zabel, Maja, Jutz, Sabrina, Steinberger, Peter, Gadermaier, Gabriele, Brocker, Thomas, Stockinger, Hannes, Derdak, Sophia, Pickl, Winfried F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117943/
https://www.ncbi.nlm.nih.gov/pubmed/37090735
http://dx.doi.org/10.3389/fimmu.2023.1094694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117943/
https://www.ncbi.nlm.nih.gov/pubmed/37090735
http://dx.doi.org/10.3389/fimmu.2023.1094694

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