Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers

Aldolase B (ALDOB) gene is essential for the process of glycolysis and differentially expressed in cancers. The aims of this study were to explore the potential role of ALDOB in pan-cancer, in order to deepen the research on the pathological mechanism of cancer. Hence, we used several online tools (...

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Autores principales: Zhao, Nannan, Xu, Haixu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118374/
https://www.ncbi.nlm.nih.gov/pubmed/37083815
http://dx.doi.org/10.1097/MD.0000000000033577
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author Zhao, Nannan
Xu, Haixu
author_facet Zhao, Nannan
Xu, Haixu
author_sort Zhao, Nannan
collection PubMed
description Aldolase B (ALDOB) gene is essential for the process of glycolysis and differentially expressed in cancers. The aims of this study were to explore the potential role of ALDOB in pan-cancer, in order to deepen the research on the pathological mechanism of cancer. Hence, we used several online tools (TIMER2, GEPIA2, UALCAN, cBioPortal, and MXPRESS) and R language to identify the correlation between the ALDOB expression and survival analysis, genetic alteration, DNA methylation, and immune cell infiltration based on The Cancer Genome Atlas project. The results showed that ALDOB was lowly expressed in pan-cancer. Survival analysis revealed that low expression of ALDOB was markedly related with poor clinical prognosis, while the genetic alteration within ALDOB changed along with the difference of overall survival (OS) and disease-free survival (DFS) prognosis in several cancers. A possible relationship between DNA methylation and ALDOB expression for several tumors was found. Besides, ALDOB expression was confirmed to be associated with tumor immune cell infiltration, especially in breast invasive carcinoma (BRCA), esophageal carcinoma (ESCA), and testicular germ cell tumors (TGCT) cases. Further, the enrichment analysis demonstrated that metabolic pathway was closely related to ALDOB expression. Our results provide a comprehensive pan-cancer analysis and suggest ALDOB could act as a promising tumor predictive biomarker for human cancer.
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spelling pubmed-101183742023-04-21 Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers Zhao, Nannan Xu, Haixu Medicine (Baltimore) 5700 Aldolase B (ALDOB) gene is essential for the process of glycolysis and differentially expressed in cancers. The aims of this study were to explore the potential role of ALDOB in pan-cancer, in order to deepen the research on the pathological mechanism of cancer. Hence, we used several online tools (TIMER2, GEPIA2, UALCAN, cBioPortal, and MXPRESS) and R language to identify the correlation between the ALDOB expression and survival analysis, genetic alteration, DNA methylation, and immune cell infiltration based on The Cancer Genome Atlas project. The results showed that ALDOB was lowly expressed in pan-cancer. Survival analysis revealed that low expression of ALDOB was markedly related with poor clinical prognosis, while the genetic alteration within ALDOB changed along with the difference of overall survival (OS) and disease-free survival (DFS) prognosis in several cancers. A possible relationship between DNA methylation and ALDOB expression for several tumors was found. Besides, ALDOB expression was confirmed to be associated with tumor immune cell infiltration, especially in breast invasive carcinoma (BRCA), esophageal carcinoma (ESCA), and testicular germ cell tumors (TGCT) cases. Further, the enrichment analysis demonstrated that metabolic pathway was closely related to ALDOB expression. Our results provide a comprehensive pan-cancer analysis and suggest ALDOB could act as a promising tumor predictive biomarker for human cancer. Lippincott Williams & Wilkins 2023-04-21 /pmc/articles/PMC10118374/ /pubmed/37083815 http://dx.doi.org/10.1097/MD.0000000000033577 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 5700
Zhao, Nannan
Xu, Haixu
Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers
title Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers
title_full Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers
title_fullStr Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers
title_full_unstemmed Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers
title_short Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers
title_sort pan-cancer analysis of aldolase b gene as a novel prognostic biomarker for human cancers
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118374/
https://www.ncbi.nlm.nih.gov/pubmed/37083815
http://dx.doi.org/10.1097/MD.0000000000033577
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