Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers
Aldolase B (ALDOB) gene is essential for the process of glycolysis and differentially expressed in cancers. The aims of this study were to explore the potential role of ALDOB in pan-cancer, in order to deepen the research on the pathological mechanism of cancer. Hence, we used several online tools (...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118374/ https://www.ncbi.nlm.nih.gov/pubmed/37083815 http://dx.doi.org/10.1097/MD.0000000000033577 |
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author | Zhao, Nannan Xu, Haixu |
author_facet | Zhao, Nannan Xu, Haixu |
author_sort | Zhao, Nannan |
collection | PubMed |
description | Aldolase B (ALDOB) gene is essential for the process of glycolysis and differentially expressed in cancers. The aims of this study were to explore the potential role of ALDOB in pan-cancer, in order to deepen the research on the pathological mechanism of cancer. Hence, we used several online tools (TIMER2, GEPIA2, UALCAN, cBioPortal, and MXPRESS) and R language to identify the correlation between the ALDOB expression and survival analysis, genetic alteration, DNA methylation, and immune cell infiltration based on The Cancer Genome Atlas project. The results showed that ALDOB was lowly expressed in pan-cancer. Survival analysis revealed that low expression of ALDOB was markedly related with poor clinical prognosis, while the genetic alteration within ALDOB changed along with the difference of overall survival (OS) and disease-free survival (DFS) prognosis in several cancers. A possible relationship between DNA methylation and ALDOB expression for several tumors was found. Besides, ALDOB expression was confirmed to be associated with tumor immune cell infiltration, especially in breast invasive carcinoma (BRCA), esophageal carcinoma (ESCA), and testicular germ cell tumors (TGCT) cases. Further, the enrichment analysis demonstrated that metabolic pathway was closely related to ALDOB expression. Our results provide a comprehensive pan-cancer analysis and suggest ALDOB could act as a promising tumor predictive biomarker for human cancer. |
format | Online Article Text |
id | pubmed-10118374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-101183742023-04-21 Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers Zhao, Nannan Xu, Haixu Medicine (Baltimore) 5700 Aldolase B (ALDOB) gene is essential for the process of glycolysis and differentially expressed in cancers. The aims of this study were to explore the potential role of ALDOB in pan-cancer, in order to deepen the research on the pathological mechanism of cancer. Hence, we used several online tools (TIMER2, GEPIA2, UALCAN, cBioPortal, and MXPRESS) and R language to identify the correlation between the ALDOB expression and survival analysis, genetic alteration, DNA methylation, and immune cell infiltration based on The Cancer Genome Atlas project. The results showed that ALDOB was lowly expressed in pan-cancer. Survival analysis revealed that low expression of ALDOB was markedly related with poor clinical prognosis, while the genetic alteration within ALDOB changed along with the difference of overall survival (OS) and disease-free survival (DFS) prognosis in several cancers. A possible relationship between DNA methylation and ALDOB expression for several tumors was found. Besides, ALDOB expression was confirmed to be associated with tumor immune cell infiltration, especially in breast invasive carcinoma (BRCA), esophageal carcinoma (ESCA), and testicular germ cell tumors (TGCT) cases. Further, the enrichment analysis demonstrated that metabolic pathway was closely related to ALDOB expression. Our results provide a comprehensive pan-cancer analysis and suggest ALDOB could act as a promising tumor predictive biomarker for human cancer. Lippincott Williams & Wilkins 2023-04-21 /pmc/articles/PMC10118374/ /pubmed/37083815 http://dx.doi.org/10.1097/MD.0000000000033577 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 5700 Zhao, Nannan Xu, Haixu Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers |
title | Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers |
title_full | Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers |
title_fullStr | Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers |
title_full_unstemmed | Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers |
title_short | Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers |
title_sort | pan-cancer analysis of aldolase b gene as a novel prognostic biomarker for human cancers |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118374/ https://www.ncbi.nlm.nih.gov/pubmed/37083815 http://dx.doi.org/10.1097/MD.0000000000033577 |
work_keys_str_mv | AT zhaonannan pancanceranalysisofaldolasebgeneasanovelprognosticbiomarkerforhumancancers AT xuhaixu pancanceranalysisofaldolasebgeneasanovelprognosticbiomarkerforhumancancers |