Accuracy of sentinel lymph node mapping in detecting occult neck metastasis in papillary thyroid carcinoma

OBJECTIVES: The objectives of this study were to evaluate the following: 1) the accuracy of sentinel lymph node mapping (SLNM) in detecting metastasis in papillary thyroid carcinoma (PTC), and 2) if SLNM could modify the American Joint Committee on Cancer (AJCC) staging of previous cN0 PTC patients....

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Autores principales: Steck, Jose Higino, Stabenow, Elaine, Bettoni, Gustavo Baldove, Steck, Samuel, Cernea, Claudio Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118789/
https://www.ncbi.nlm.nih.gov/pubmed/29791655
http://dx.doi.org/10.20945/2359-3997000000038
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author Steck, Jose Higino
Stabenow, Elaine
Bettoni, Gustavo Baldove
Steck, Samuel
Cernea, Claudio Roberto
author_facet Steck, Jose Higino
Stabenow, Elaine
Bettoni, Gustavo Baldove
Steck, Samuel
Cernea, Claudio Roberto
author_sort Steck, Jose Higino
collection PubMed
description OBJECTIVES: The objectives of this study were to evaluate the following: 1) the accuracy of sentinel lymph node mapping (SLNM) in detecting metastasis in papillary thyroid carcinoma (PTC), and 2) if SLNM could modify the American Joint Committee on Cancer (AJCC) staging of previous cN0 PTC patients. SUBJECTS AND METHODS: Forty SLNM were performed prospectively in 38 consecutive cN0 PTC patients, with total thyroidectomy and elective compartment neck dissection (CND). The results of SLNM were compared with CND pathological findings to verify the accuracy of sentinel SLNM. RESULTS: The mean patients’ follow-up was 36 months. A total of 133 SLN were found at levels VI, II, III and IV. The SLN was identified in 95% of the patients with one false negative, 95% sensitivity, a 94% negative predictive value and 97% accuracy. The SLNM upstaging from cN0 to pN+ was 49%, and to stages III and IVa, it was 21%. CONCLUSIONS: For this series of cN0 PTC patients: 1) SLNM accuracy was 97%, and 2) SLNM upstaging from cN0 to pN+ was 49%, whereas to stages III and IVa, it was 21%.
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spelling pubmed-101187892023-04-21 Accuracy of sentinel lymph node mapping in detecting occult neck metastasis in papillary thyroid carcinoma Steck, Jose Higino Stabenow, Elaine Bettoni, Gustavo Baldove Steck, Samuel Cernea, Claudio Roberto Arch Endocrinol Metab Original Article OBJECTIVES: The objectives of this study were to evaluate the following: 1) the accuracy of sentinel lymph node mapping (SLNM) in detecting metastasis in papillary thyroid carcinoma (PTC), and 2) if SLNM could modify the American Joint Committee on Cancer (AJCC) staging of previous cN0 PTC patients. SUBJECTS AND METHODS: Forty SLNM were performed prospectively in 38 consecutive cN0 PTC patients, with total thyroidectomy and elective compartment neck dissection (CND). The results of SLNM were compared with CND pathological findings to verify the accuracy of sentinel SLNM. RESULTS: The mean patients’ follow-up was 36 months. A total of 133 SLN were found at levels VI, II, III and IV. The SLN was identified in 95% of the patients with one false negative, 95% sensitivity, a 94% negative predictive value and 97% accuracy. The SLNM upstaging from cN0 to pN+ was 49%, and to stages III and IVa, it was 21%. CONCLUSIONS: For this series of cN0 PTC patients: 1) SLNM accuracy was 97%, and 2) SLNM upstaging from cN0 to pN+ was 49%, whereas to stages III and IVa, it was 21%. Sociedade Brasileira de Endocrinologia e Metabologia 2018-05-07 /pmc/articles/PMC10118789/ /pubmed/29791655 http://dx.doi.org/10.20945/2359-3997000000038 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Steck, Jose Higino
Stabenow, Elaine
Bettoni, Gustavo Baldove
Steck, Samuel
Cernea, Claudio Roberto
Accuracy of sentinel lymph node mapping in detecting occult neck metastasis in papillary thyroid carcinoma
title Accuracy of sentinel lymph node mapping in detecting occult neck metastasis in papillary thyroid carcinoma
title_full Accuracy of sentinel lymph node mapping in detecting occult neck metastasis in papillary thyroid carcinoma
title_fullStr Accuracy of sentinel lymph node mapping in detecting occult neck metastasis in papillary thyroid carcinoma
title_full_unstemmed Accuracy of sentinel lymph node mapping in detecting occult neck metastasis in papillary thyroid carcinoma
title_short Accuracy of sentinel lymph node mapping in detecting occult neck metastasis in papillary thyroid carcinoma
title_sort accuracy of sentinel lymph node mapping in detecting occult neck metastasis in papillary thyroid carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118789/
https://www.ncbi.nlm.nih.gov/pubmed/29791655
http://dx.doi.org/10.20945/2359-3997000000038
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