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Recreation of an antigen-driven germinal center in vitro by providing B cells with phagocytic antigen
Successful vaccines rely on activating a functional humoral immune response through the generation of class-switched high affinity immunoglobulins (Igs). The germinal center (GC) reaction is crucial for this process, in which B cells are selected in their search for antigen and T cell help. A major...
Autores principales: | Martínez-Riaño, Ana, Delgado, Pilar, Tercero, Rut, Barrero, Sara, Mendoza, Pilar, Oeste, Clara L., Abia, David, Rodríguez-Bovolenta, Elena, Turner, Martin, Alarcón, Balbino |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119099/ https://www.ncbi.nlm.nih.gov/pubmed/37081131 http://dx.doi.org/10.1038/s42003-023-04807-0 |
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