Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma

The Wnt pathway is frequently dysregulated in many cancers, underscoring it as a therapeutic target. Wnt inhibitors have uniformly failed in clinical trials. Here, we report a mechanism of WNT pathway activation through the Semaphorin 3 C neurodevelopmental program in glioma stem-like cells. Sema3C...

Descripción completa

Detalles Bibliográficos
Autores principales: Hao, Jing, Han, Xiangzi, Huang, Haidong, Yu, Xingjiang, Fang, Jiankang, Zhao, Jianjun, Prayson, Richard A., Bao, Shideng, Yu, Jennifer S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119166/
https://www.ncbi.nlm.nih.gov/pubmed/37080989
http://dx.doi.org/10.1038/s41467-023-37397-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119166/
https://www.ncbi.nlm.nih.gov/pubmed/37080989
http://dx.doi.org/10.1038/s41467-023-37397-w

Ejemplares similares