The intracellular domain of major histocompatibility class-I proteins is essential for maintaining excitatory spine density and synaptic ultrastructure in the brain

Major histocompatibility complex class I (MHC-I) proteins are expressed in neurons, where they regulate synaptic plasticity. However, the mechanisms by which MHC-I functions in the CNS remains unknown. Here we describe the first structural analysis of a MHC-I protein, to resolve underlying mechanism...

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Detalles Bibliográficos
Autores principales: Lazarczyk, Maciej J., Eyford, Brett A., Varghese, Merina, Arora, Hitesh, Munro, Lonna, Warda, Tahia, Pfeifer, Cheryl G., Sowa, Allison, Dickstein, Daniel R., Rumbell, Timothy, Jefferies, Wilfred A., Dickstein, Dara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119172/
https://www.ncbi.nlm.nih.gov/pubmed/37081001
http://dx.doi.org/10.1038/s41598-023-30054-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119172/
https://www.ncbi.nlm.nih.gov/pubmed/37081001
http://dx.doi.org/10.1038/s41598-023-30054-8

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