Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism

Lipid interaction with α-synuclein (αSyn) has been long implicated in the pathogenesis of Parkinson’s disease (PD). However, it has not been fully determined which lipids are involved in the initiation of αSyn aggregation in PD. Here exploiting genetic understanding associating the loss-of-function...

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Detalles Bibliográficos
Autores principales: Choong, Chi-Jing, Aguirre, César, Kakuda, Keita, Beck, Goichi, Nakanishi, Hiroki, Kimura, Yasuyoshi, Shimma, Shuichi, Nabekura, Kei, Hideshima, Makoto, Doi, Junko, Yamaguchi, Keiichi, Nakajima, Kichitaro, Wadayama, Tomoya, Hayakawa, Hideki, Baba, Kousuke, Ogawa, Kotaro, Takeuchi, Toshihide, Badawy, Shaymaa Mohamed Mohamed, Murayama, Shigeo, Nagano, Seiichi, Goto, Yuji, Miyanoiri, Yohei, Nagai, Yoshitaka, Mochizuki, Hideki, Ikenaka, Kensuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119223/
https://www.ncbi.nlm.nih.gov/pubmed/36939875
http://dx.doi.org/10.1007/s00401-023-02555-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119223/
https://www.ncbi.nlm.nih.gov/pubmed/36939875
http://dx.doi.org/10.1007/s00401-023-02555-3

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