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Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism
Lipid interaction with α-synuclein (αSyn) has been long implicated in the pathogenesis of Parkinson’s disease (PD). However, it has not been fully determined which lipids are involved in the initiation of αSyn aggregation in PD. Here exploiting genetic understanding associating the loss-of-function...
Autores principales: | Choong, Chi-Jing, Aguirre, César, Kakuda, Keita, Beck, Goichi, Nakanishi, Hiroki, Kimura, Yasuyoshi, Shimma, Shuichi, Nabekura, Kei, Hideshima, Makoto, Doi, Junko, Yamaguchi, Keiichi, Nakajima, Kichitaro, Wadayama, Tomoya, Hayakawa, Hideki, Baba, Kousuke, Ogawa, Kotaro, Takeuchi, Toshihide, Badawy, Shaymaa Mohamed Mohamed, Murayama, Shigeo, Nagano, Seiichi, Goto, Yuji, Miyanoiri, Yohei, Nagai, Yoshitaka, Mochizuki, Hideki, Ikenaka, Kensuke |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119223/ https://www.ncbi.nlm.nih.gov/pubmed/36939875 http://dx.doi.org/10.1007/s00401-023-02555-3 |
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