Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties

The Notch signaling pathway is an important therapeutic target for the treatment of inflammatory diseases and cancer. We previously created ligand-specific inhibitors of Notch signaling comprised of Fc fusions to specific EGF-like repeats of the Notch1 extracellular domain, called Notch decoys, whic...

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Detalles Bibliográficos
Autores principales: Sargis, Timothy, Youn, Seock-Won, Thakkar, Krishna, Naiche, L. A., Paik, Na Yoon, Pajcini, Kostandin V., Kitajewski, Jan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119233/
https://www.ncbi.nlm.nih.gov/pubmed/36376768
http://dx.doi.org/10.1007/s10456-022-09861-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119233/
https://www.ncbi.nlm.nih.gov/pubmed/36376768
http://dx.doi.org/10.1007/s10456-022-09861-6

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