Cargando…

Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties

The Notch signaling pathway is an important therapeutic target for the treatment of inflammatory diseases and cancer. We previously created ligand-specific inhibitors of Notch signaling comprised of Fc fusions to specific EGF-like repeats of the Notch1 extracellular domain, called Notch decoys, whic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sargis, Timothy, Youn, Seock-Won, Thakkar, Krishna, Naiche, L. A., Paik, Na Yoon, Pajcini, Kostandin V., Kitajewski, Jan K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2022
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119233/ https://www.ncbi.nlm.nih.gov/pubmed/36376768 http://dx.doi.org/10.1007/s10456-022-09861-6

Ejemplares similares

Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
por: Greene, Maxwell, et al.
Publicado: (2016)

Notch Signaling in the Bone Marrow Lymphopoietic Niche
por: Sottoriva, Kilian, et al.
Publicado: (2021)

Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration
por: Swaminathan, Bhairavi, et al.
Publicado: (2022)

A Notch/IL-21 signaling axis primes bone marrow T cell progenitor expansion
por: Sottoriva, Kilian, et al.
Publicado: (2022)

Dlk1-Mediated Temporal Regulation of Notch Signaling Is Required for Differentiation of Alveolar Type II to Type I Cells during Repair
por: Finn, Johanna, et al.
Publicado: (2019)

Notch regulates the angiogenic response via induction of VEGFR-1
por: Funahashi, Yasuhiro, et al.
Publicado: (2010)

Notch1 promotes ordered revascularization through Semaphorin 3g modulation of downstream vascular patterning signalling factors
por: Hyun, James, et al.
Publicado: (2022)

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands
por: Suckling, Richard J, et al.
Publicado: (2017)

Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL
por: Stein, Sarah J., et al.
Publicado: (2016)

Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands
por: Chillakuri, Chandramouli R., et al.
Publicado: (2013)

A Tie2-Notch1 signaling axis regulates regeneration of the endothelial bone marrow niche
por: Shao, Lijian, et al.
Publicado: (2019)

Unique functions for Notch4 in murine embryonic lymphangiogenesis
por: Muley, Ajit, et al.
Publicado: (2021)

Notch receptor–ligand binding and activation: Insights from molecular studies
por: Chillakuri, Chandramouli R., et al.
Publicado: (2012)

Vascular Notch proteins and Notch signaling in the peri-implantation mouse uterus
por: Shawber, Carrie J., et al.
Publicado: (2015)

Bioengineered peptibodies as blockers of ion channels
por: Chidipi, Bojjibabu, et al.
Publicado: (2022)

Notch3 signaling promotes tumor cell adhesion and progression in a murine epithelial ovarian cancer model
por: Price, Jessica C., et al.
Publicado: (2020)

The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells
por: Gerhardt, Dawson M., et al.
Publicado: (2014)

Cis-interactions between Notch and its ligands block ligand-independent Notch activity
por: Palmer, William Hunt, et al.
Publicado: (2014)

VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis
por: Thurston, G, et al.
Publicado: (2008)

Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations
por: Kofler, Natalie M., et al.
Publicado: (2015)

The Role of Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation
por: Hounjet, Judith, et al.
Publicado: (2021)

Peptibody Based on FGFR1-Binding Peptides From the FGF4 Sequence as a Cancer-Targeting Agent
por: Jendryczko, Karolina, et al.
Publicado: (2021)

Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1α
por: Tsang, Kit Man, et al.
Publicado: (2017)

The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis
por: Kandachar, Vasundhara, et al.
Publicado: (2008)

A new model of Notch signalling: Control of Notch receptor cis-inhibition via Notch ligand dimers
por: Chen, Daipeng, et al.
Publicado: (2023)

A Glycosphingolipid Binding Domain Controls Trafficking and Activity of the Mammalian Notch Ligand Delta-Like 1
por: Heuss, Sara Farrah, et al.
Publicado: (2013)

A Review of Notch Processing With New Insights Into Ligand-Independent Notch Signaling in T-Cells
por: Steinbuck, Martin Peter, et al.
Publicado: (2018)

Enhanced Delta-Notch Lateral Inhibition Model Incorporating Intracellular Notch Heterogeneity and Tension-Dependent Rate of Delta-Notch Binding that Reproduces Sprouting Angiogenesis Patterns
por: Koon, Yen Ling, et al.
Publicado: (2018)

Notch1 binds and induces degradation of Snail in hepatocellular carcinoma
por: Lim, Seung-Oe, et al.
Publicado: (2011)

Src kinase phosphorylates Notch1 to inhibit MAML binding
por: LaFoya, Bryce, et al.
Publicado: (2018)

In vivo consequences of deleting EGF repeats 8–12 including the ligand binding domain of mouse Notch1
por: Ge, Changhui, et al.
Publicado: (2008)

Comparative analysis of Notch1 and Notch2 binding sites in the genome of BxPC3 pancreatic cancer cells
por: Liu, Hao, et al.
Publicado: (2017)

Notch1 activates angiogenic regulator Netrin4 in endothelial cells
por: Liu, Qiang, et al.
Publicado: (2019)

Expression, purification and biological activity assessment of romiplostim biosimilar peptibody
por: Fayaz, Shima, et al.
Publicado: (2016)

The Expression of Notch/Notch Ligand, IL-35, IL-17, and Th17/Treg in Preeclampsia
por: Cao, Weiping, et al.
Publicado: (2015)

Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium
por: Hirano, Ken-ichi, et al.
Publicado: (2022)

Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesis
por: Hernandez, Sonia L, et al.
Publicado: (2013)

Dynamic Ligand Discrimination in the Notch Signaling Pathway
por: Nandagopal, Nagarajan, et al.
Publicado: (2018)

Diversity in Notch ligand-receptor signaling interactions
por: Kuintzle, Rachael, et al.
Publicado: (2023)

Molecular docking analysis of phytocompounds from Andrographis paniculata binding with proteins in the notch-signaling pathway
por: Deiva Suga, Sumetha Suga, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_akpge61epd6gk72cgu4750b7er