Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology

Amyotrophic Lateral Sclerosis (ALS) causes motor neuron degeneration, with 97% of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been hampered by disease heterogeneity and difficulties accessing motor neurons. Human induced pluripotent stem cell-derived motor neurons (iPSMNs)...

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Detalles Bibliográficos
Autores principales: Ziff, Oliver J., Neeves, Jacob, Mitchell, Jamie, Tyzack, Giulia, Martinez-Ruiz, Carlos, Luisier, Raphaelle, Chakrabarti, Anob M., McGranahan, Nicholas, Litchfield, Kevin, Boulton, Simon J., Al-Chalabi, Ammar, Kelly, Gavin, Humphrey, Jack, Patani, Rickie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119258/
https://www.ncbi.nlm.nih.gov/pubmed/37080969
http://dx.doi.org/10.1038/s41467-023-37630-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119258/
https://www.ncbi.nlm.nih.gov/pubmed/37080969
http://dx.doi.org/10.1038/s41467-023-37630-6

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