AGGF1 therapy inhibits thoracic aortic aneurysms by enhancing integrin α7-mediated inhibition of TGF-β1 maturation and ERK1/2 signaling

Thoracic aortic aneurysm (TAA) is a localized or diffuse dilatation of the thoracic aortas, and causes many sudden deaths each year worldwide. However, there is no effective pharmacologic therapy. Here, we show that AGGF1 effectively blocks TAA-associated arterial inflammation and remodeling in thre...

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Detalles Bibliográficos
Autores principales: Da, Xingwen, Li, Ziyan, Huang, Xiaofan, He, Zuhan, Yu, Yubing, Tian, Tongtong, Xu, Chengqi, Yao, Yufeng, Wang, Qing K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119315/
https://www.ncbi.nlm.nih.gov/pubmed/37081014
http://dx.doi.org/10.1038/s41467-023-37809-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119315/
https://www.ncbi.nlm.nih.gov/pubmed/37081014
http://dx.doi.org/10.1038/s41467-023-37809-x

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