Preclinical Interventions in Mouse Models of Frontotemporal Dementia Due to Progranulin Mutations

Heterozygous loss-of-function mutations in progranulin (GRN) cause frontotemporal dementia (FTD), a leading cause of early-onset dementia characterized clinically by behavioral, social, and language deficits. There are currently no FDA-approved therapeutics for FTD-GRN, but this has been an active a...

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Detalles Bibliográficos
Autores principales: Kashyap, Shreya N., Boyle, Nicholas R., Roberson, Erik D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119358/
https://www.ncbi.nlm.nih.gov/pubmed/36781744
http://dx.doi.org/10.1007/s13311-023-01348-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119358/
https://www.ncbi.nlm.nih.gov/pubmed/36781744
http://dx.doi.org/10.1007/s13311-023-01348-6

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