From PERK to RIPK1: Design, synthesis and evaluation of novel potent and selective necroptosis inhibitors

Receptor-Interacting serine/threonine-Protein Kinase 1 (RIPK1) emerged as an important driver of inflammation and, consequently, inflammatory pathologies. The enzymatic activity of RIPK1 is known to indirectly promote inflammation by triggering cell death, in the form of apoptosis, necroptosis and p...

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Detalles Bibliográficos
Autores principales: Scarpellini, Camilla, Valembois, Sophie, Goossens, Kenneth, Vadi, Mike, Lanthier, Caroline, Klejborowska, Greta, Van Der Veken, Pieter, De Winter, Hans, Bertrand, Mathieu J. M., Augustyns, Koen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119423/
https://www.ncbi.nlm.nih.gov/pubmed/37090247
http://dx.doi.org/10.3389/fchem.2023.1160164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119423/
https://www.ncbi.nlm.nih.gov/pubmed/37090247
http://dx.doi.org/10.3389/fchem.2023.1160164

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