Separate roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of FV and FVIII

Mutations in lectin, mannose-binding 1 (LMAN1) and multiple coagulation factor deficiency protein 2 (MCFD2) cause the combined deficiency of factor V (FV) and FVIII (F5F8D). LMAN1 and MCFD2 form a protein complex that transports FV and FVIII from the endoplasmic reticulum (ER) to the Golgi. Although...

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Detalles Bibliográficos
Autores principales: Zhang, Yuan, Liu, Zhigang, Zhang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119632/
https://www.ncbi.nlm.nih.gov/pubmed/36490287
http://dx.doi.org/10.1182/bloodadvances.2022008788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119632/
https://www.ncbi.nlm.nih.gov/pubmed/36490287
http://dx.doi.org/10.1182/bloodadvances.2022008788

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