trans-Cyclooctene- and Bicyclononyne-Linked Nucleotides for Click Modification of DNA with Fluorogenic Tetrazines and Live Cell Metabolic Labeling and Imaging

[Image: see text] A series of 2′-deoxyribonucleoside triphosphates (dNTPs) bearing 2- or 4-linked trans-cyclooctene (TCO) or bicyclononyne (BCN) tethered through a shorter propargylcarbamate or longer triethyleneglycol-based spacer were designed and synthesized. They were found to be good substrates...

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Detalles Bibliográficos
Autores principales: Spampinato, Ambra, Kužmová, Erika, Pohl, Radek, Sýkorová, Veronika, Vrábel, Milan, Kraus, Tomáš, Hocek, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119924/
https://www.ncbi.nlm.nih.gov/pubmed/36972479
http://dx.doi.org/10.1021/acs.bioconjchem.3c00064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119924/
https://www.ncbi.nlm.nih.gov/pubmed/36972479
http://dx.doi.org/10.1021/acs.bioconjchem.3c00064

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