A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes

Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in various neurodegenerative diseases. This deleterious effect is mediated by pathological cleavage of the Cdk5 activator p35 into the truncated product p25, leading to prolonged Cdk5 activation and altered substrate specificity...

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Detalles Bibliográficos
Autores principales: Pao, Ping-Chieh, Seo, Jinsoo, Lee, Audrey, Kritskiy, Oleg, Patnaik, Debasis, Penney, Jay, Raju, Ravikiran M., Geigenmuller, Ute, Silva, M. Catarina, Lucente, Diane E., Gusella, James F., Dickerson, Bradford C., Loon, Anjanet, Yu, Margaret X., Bula, Michael, Yu, Melody, Haggarty, Stephen J., Tsai, Li-Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120002/
https://www.ncbi.nlm.nih.gov/pubmed/37043533
http://dx.doi.org/10.1073/pnas.2217864120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120002/
https://www.ncbi.nlm.nih.gov/pubmed/37043533
http://dx.doi.org/10.1073/pnas.2217864120

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