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Lipid droplets are intracellular mechanical stressors that impair hepatocyte function

Matrix stiffening and external mechanical stress have been linked to disease and cancer development in multiple tissues, including the liver, where cirrhosis (which increases stiffness markedly) is the major risk factor for hepatocellular carcinoma. Patients with nonalcoholic fatty liver disease and...

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Detalles Bibliográficos
Autores principales: Loneker, Abigail E., Alisafaei, Farid, Kant, Aayush, Li, David, Janmey, Paul A., Shenoy, Vivek B., Wells, Rebecca G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120019/
https://www.ncbi.nlm.nih.gov/pubmed/37036981
http://dx.doi.org/10.1073/pnas.2216811120