STAT2 hinders STING intracellular trafficking and reshapes its activation in response to DNA damage

In cancer cells, endogenous or therapy-induced DNA damage leads to the abnormal presence of DNA in the cytoplasm, which triggers the activation of cGAS (cyclic GMP–AMP synthase) and STING (stimulator of interferon genes). STAT2 suppresses the cGAMP-induced expression of IRF3-dependent genes by bindi...

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Detalles Bibliográficos
Autores principales: Wang, Chenyao, Nan, Jing, Holvey-Bates, Elise, Chen, Xing, Wightman, Samantha, Latif, Muhammad-Bilal, Zhao, Junjie, Li, Xiaoxia, Sen, Ganes C., Stark, George R., Wang, Yuxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120020/
https://www.ncbi.nlm.nih.gov/pubmed/37036972
http://dx.doi.org/10.1073/pnas.2216953120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120020/
https://www.ncbi.nlm.nih.gov/pubmed/37036972
http://dx.doi.org/10.1073/pnas.2216953120

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