Evidence supporting the MICU1 occlusion mechanism and against the potentiation model in the mitochondrial calcium uniporter complex

The mitochondrial calcium uniporter is a Ca(2+) channel that imports cytoplasmic Ca(2+) into the mitochondrial matrix to regulate cell bioenergetics, intracellular Ca(2+) signaling, and apoptosis. The uniporter contains the pore-forming MCU subunit, an auxiliary EMRE protein, and the regulatory MICU...

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Detalles Bibliográficos
Autores principales: Tsai, Chen-Wei, Liu, Tsung-Yun, Chao, Fan-Yi, Tu, Yung-Chi, Rodriguez, Madison X., Van Keuren, Anna M., Ma, Zhiwei, Bankston, John, Tsai, Ming-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120041/
https://www.ncbi.nlm.nih.gov/pubmed/37036971
http://dx.doi.org/10.1073/pnas.2217665120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120041/
https://www.ncbi.nlm.nih.gov/pubmed/37036971
http://dx.doi.org/10.1073/pnas.2217665120

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