Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome

Trisomy 21 and mutations in the Sonic hedgehog (SHH) signaling pathway cause overlapping and pleiotropic phenotypes including cerebellar hypoplasia, craniofacial abnormalities, congenital heart defects and Hirschsprung disease. Trisomic cells derived from individuals with Down syndrome possess defic...

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Detalles Bibliográficos
Autores principales: Moyer, Anna J., Fernandez, Fabian-Xosé, Li, Yicong, Klinedinst, Donna K., Florea, Liliana D., Kazuki, Yasuhiro, Oshimura, Mitsuo, Reeves, Roger H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120076/
https://www.ncbi.nlm.nih.gov/pubmed/36995257
http://dx.doi.org/10.1242/dmm.049712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120076/
https://www.ncbi.nlm.nih.gov/pubmed/36995257
http://dx.doi.org/10.1242/dmm.049712

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