ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1

The hypoxia-inducible factor 1-α (HIF-1α) enables cells to adapt and respond to hypoxia (Hx), and the activity of this transcription factor is regulated by several oncogenic signals and cellular stressors. While the pathways controlling normoxic degradation of HIF-1α are well understood, the mechani...

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Detalles Bibliográficos
Autores principales: Mayro, Benjamin, Hoj, Jacob P., Cerda-Smith, Christian G., Hutchinson, Haley M., Caminear, Michael W., Thrash, Hannah L., Winter, Peter S., Wardell, Suzanne E., McDonnell, Donald P., Wu, Colleen, Wood, Kris C., Pendergast, Ann Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120083/
https://www.ncbi.nlm.nih.gov/pubmed/37040401
http://dx.doi.org/10.1073/pnas.2210418120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120083/
https://www.ncbi.nlm.nih.gov/pubmed/37040401
http://dx.doi.org/10.1073/pnas.2210418120

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