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PP1γ regulates neuronal insulin signaling and aggravates insulin resistance leading to AD-like phenotypes

BACKGROUND: PP1γ is one of the isoforms of catalytic subunit of a Ser/Thr phosphatase PP1. The role of PP1γ in cellular regulation is largely unknown. The present study investigated the role of PP1γ in regulating neuronal insulin signaling and insulin resistance in neuronal cells. PP1 was inhibited...

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Detalles Bibliográficos
Autores principales: Yadav, Yamini, Sharma, Medha, Dey, Chinmoy Sankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120118/
https://www.ncbi.nlm.nih.gov/pubmed/37085815
http://dx.doi.org/10.1186/s12964-023-01071-x