Cargando…

PP1γ regulates neuronal insulin signaling and aggravates insulin resistance leading to AD-like phenotypes

BACKGROUND: PP1γ is one of the isoforms of catalytic subunit of a Ser/Thr phosphatase PP1. The role of PP1γ in cellular regulation is largely unknown. The present study investigated the role of PP1γ in regulating neuronal insulin signaling and insulin resistance in neuronal cells. PP1 was inhibited...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yadav, Yamini, Sharma, Medha, Dey, Chinmoy Sankar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120118/ https://www.ncbi.nlm.nih.gov/pubmed/37085815 http://dx.doi.org/10.1186/s12964-023-01071-x

Ejemplares similares

PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble
por: Sharma, Medha, et al.
Publicado: (2022)

PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance
por: Gupta, Amit, et al.
Publicado: (2012)

Focal Adhesion Kinase contributes to insulin-induced actin reorganization into a mesh harboring Glucose transporter-4 in insulin resistant skeletal muscle cells
por: Bisht, Bharti, et al.
Publicado: (2008)

Statins Aggravate the Risk of Insulin Resistance in Human Muscle
por: Grunwald, Stefanie A., et al.
Publicado: (2022)

Two-headed outer- and inner-arm dyneins of Leishmania sp bear conserved IQ-like motifs
por: Mukhopadhyay, Aakash Gautam, et al.
Publicado: (2015)

Aggravation of post-ischemic liver injury by overexpression of insulin-like growth factor binding protein 3
por: Zhou, Lu, et al.
Publicado: (2015)

Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity
por: Yamamoto, Soh, et al.
Publicado: (2018)

Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity
por: Leonardini, Anna, et al.
Publicado: (2009)

Upregulation of Klotho Aggravates Insulin Resistance in Gestational Diabetes Mellitus Trophoblast Cells
por: Lin, Li, et al.
Publicado: (2022)

Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas
por: Wright, Jordan J., et al.
Publicado: (2023)

Mutations in the C1 element of the insulin promoter lead to diabetic phenotypes in homozygous mice
por: Noguchi, Hirofumi, et al.
Publicado: (2020)

Acute Kidney Injury-Associated Systemic Inflammation Is Aggravated in Insulin-Dependent Diabetes Mellitus
por: Patschan, Daniel, et al.
Publicado: (2019)

Randomized Comparison of Pramlintide or Mealtime Insulin Added to Basal Insulin Treatment for Patients With Type 2 Diabetes
por: Riddle, Matthew, et al.
Publicado: (2009)

An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology
por: Fernandes de Abreu, Diana Andrea, et al.
Publicado: (2014)

Role of Insulin-like Growth Factor, Insulin-like Growth Factor Receptors, and Insulin-like Growth Factor-binding Proteins in Ovarian Cancer
por: Amutha, Periyasamy, et al.
Publicado: (2017)

Insulin and insulin like growth factor II endocytosis and signaling via insulin receptor B
por: Giudice, Jimena, et al.
Publicado: (2013)

Reactivation of flagellar motility in demembranated Leishmania reveals role of cAMP in flagellar wave reversal to ciliary waveform
por: Mukhopadhyay, Aakash Gautam, et al.
Publicado: (2016)

Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic mice
por: Perruolo, Giuseppe, et al.
Publicado: (2016)

Astrocytic Insulin-Like Growth Factor-1 Protects Neurons Against Excitotoxicity
por: Chen, Wei, et al.
Publicado: (2019)

The Impact of Adding Prandial Insulin to a Basal Based Regimen with Insulin Glargine in Type 2 Diabetic Patients
por: Khamseh, Mohammad Ebrahim, et al.
Publicado: (2021)

The vascular function effects of adding exenatide or meal insulin to basal insulin therapy in early type 2 diabetes
por: Retnakaran, Ravi, et al.
Publicado: (2023)

Targeting Insulin-Like Growth Factor 1 Leads to Amelioration of Inflammatory Demyelinating Disease
por: Cusick, Matthew F., et al.
Publicado: (2014)

Helicobacter pylori Infection Aggravates Diet-induced Insulin Resistance in Association With Gut Microbiota of Mice
por: He, Cong, et al.
Publicado: (2016)

Myeloid FBW7 deficiency disrupts redox homeostasis and aggravates dietary-induced insulin resistance
por: Wang, Cheng, et al.
Publicado: (2020)

Insulin Assay Standardization: Leading to measures of insulin sensitivity and secretion for practical clinical care
por: Staten, Myrlene A., et al.
Publicado: (2010)

SUN-186 Insulin Antibody Associated Severe Insulin Resistance Leading to Uncontrolled Hyperglycemia
por: Amir, Hajira, et al.
Publicado: (2019)

Insulin/Insulin-Like Growth Factor-1 Pathway in Barrett's Carcinogenesis
por: Greer, K B, et al.
Publicado: (2013)

Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production
por: Perez-Frances, Marta, et al.
Publicado: (2021)

Chungkookjang with High Contents of Poly-γ-Glutamic Acid Improves Insulin Sensitizing Activity in Adipocytes and Neuronal Cells
por: Jeong, Seong-Yeop, et al.
Publicado: (2018)

Insulin, insulin-like growth factor–1, insulin receptor, and insulin-like growth factor–1 receptor expression in the chick eye and their regulation with imposed myopic or hyperopic defocus
por: Penha, Alexandra Marcha, et al.
Publicado: (2011)

Comparison of Combined Tofogliflozin and Glargine, Tofogliflozin Added to Insulin, and Insulin Dose-Increase Therapy in Uncontrolled Type 2 Diabetes
por: Suzuki, Katsunori, et al.
Publicado: (2016)

Exenatide versus Insulin Lispro Added to Basal Insulin in a Subgroup of Korean Patients with Type 2 Diabetes Mellitus
por: Yoon, Kun-Ho, et al.
Publicado: (2017)

How does obesity lead to insulin resistance?
por: Choi, Chan Hee J, et al.
Publicado: (2017)

How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor
por: Xu, Yibin, et al.
Publicado: (2022)

Efficacy and Safety of Low Dose Insulin Infusion against Standard Dose Insulin Infusion in Children with Diabetic Ketoacidosis- An Open Labelled Randomized Controlled Trial
por: Saikia, Diganta, et al.
Publicado: (2022)

Microsatellite and Single Nucleotide Polymorphisms in the Insulin-Like Growth Factor 1 Promoter with Insulin Sensitivity and Insulin Secretion
por: Wang, Ruyao, et al.
Publicado: (2017)

Insulin Receptor Substrate 2 Expression and Involvement in Neuronal Insulin Resistance in Diabetic Neuropathy
por: Grote, C. W., et al.
Publicado: (2011)

Blood Lead Levels and Serum Insulin-Like Growth Factor 1 Concentrations in Peripubertal Boys
por: Fleisch, Abby F., et al.
Publicado: (2013)

Brain PPARγ Promotes Obesity and is Required for the Insulin–Sensitizing Effect of Thiazolidinediones
por: Lu, Min, et al.
Publicado: (2011)

Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons
por: Claros, Silvia, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qae8eijh9l93tc5tl5023r591d