YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2

BACKGROUND: Ocular neovascularization is a leading cause of blindness. Retinal microglia have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the underlying mechanisms are not entirely clear. Lactylation is a novel lactate-derived posttranslational modification that plays key r...

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Detalles Bibliográficos
Autores principales: Wang, Xiaotang, Fan, Wei, Li, Na, Ma, Yan, Yao, Mudi, Wang, Guoqing, He, Siyuan, Li, Wanqian, Tan, Jun, Lu, Qi, Hou, Shengping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120156/
https://www.ncbi.nlm.nih.gov/pubmed/37085894
http://dx.doi.org/10.1186/s13059-023-02931-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120156/
https://www.ncbi.nlm.nih.gov/pubmed/37085894
http://dx.doi.org/10.1186/s13059-023-02931-y

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